Originally published on cell.com
“Exercise has many positive effects on the body, including improved blood circulation, heart strengthening, and weight control. Kurz et al. report that aerobic exercise is also associated with reduced tumor growth in models of pancreatic ductal adenocarcinoma. They showed that exercise enhanced the survival of a type of immune cell called CD8+ T lymphocytes, which are known for their ability to kill tumors. Greater numbers of CD8+ T cells capable of infiltrating tumors were found to accumulate as a result of an exercise regimen. The anti-tumor effects were mediated through the interleukin-15 (IL-15) axis, and pharmacological targeting of the IL-15/IL-15Rα pathway slowed tumor growth, particularly when combined with immunotherapy and chemotherapy treatments.”
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